7zl9: Difference between revisions
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==Crystal structure of human GPCR Niacin receptor (HCA2)== | |||
<StructureSection load='7zl9' size='340' side='right'caption='[[7zl9]], [[Resolution|resolution]] 2.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7zl9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZL9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZL9 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zl9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zl9 OCA], [https://pdbe.org/7zl9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zl9 RCSB], [https://www.ebi.ac.uk/pdbsum/7zl9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zl9 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.[https://www.uniprot.org/uniprot/HCAR2_HUMAN HCAR2_HUMAN] Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.<ref>PMID:17932499</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Escherichia coli]] | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: FiBerto JF]] | |||
[[Category: Gao RG]] | |||
[[Category: Han GW]] | |||
[[Category: Kang HJ]] | |||
[[Category: Kenakin T]] | |||
[[Category: Li XM]] | |||
[[Category: Liu ZJ]] | |||
[[Category: Peng W]] | |||
[[Category: Pileski R]] | |||
[[Category: Qu L]] | |||
[[Category: Rao ZH]] | |||
[[Category: Roth BL]] | |||
[[Category: Stevens RC]] | |||
[[Category: Tong JH]] | |||
[[Category: Wang JJ]] | |||
[[Category: Wang Q]] | |||
[[Category: Wu LJ]] | |||
[[Category: Wu YR]] | |||
[[Category: Yang Y]] | |||
[[Category: Zhang XC]] | |||
[[Category: Zhao SW]] | |||
Latest revision as of 08:04, 7 February 2024
Crystal structure of human GPCR Niacin receptor (HCA2)
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