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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3j32]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Haliotis_diversicolor Haliotis diversicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J32 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J32 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3j32]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Haliotis_diversicolor Haliotis diversicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J32 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J32 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j32 OCA], [https://pdbe.org/3j32 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j32 RCSB], [https://www.ebi.ac.uk/pdbsum/3j32 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j32 ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j32 OCA], [https://pdbe.org/3j32 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j32 RCSB], [https://www.ebi.ac.uk/pdbsum/3j32 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j32 ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/C7FEG7_HALDV C7FEG7_HALDV]
Hemocyanins are responsible for transporting O2 in the arthropod and molluscan hemolymph. Haliotis diversicolor molluscan hemocyanin isoform 1 (HdH1) is an 8 MDa oligomer. Each subunit is made up of eight functional units (FUs). Each FU contains two Cu ions, which can reversibly bind an oxygen molecule. Here, we report a 4.5 A cryo-EM structure of HdH1. The structure clearly shows ten asymmetric units arranged with D5 symmetry. Each asymmetric unit contains two structurally distinct but chemically identical subunits. The map is sufficiently resolved to trace the entire subunit Calpha backbone and to visualize densities corresponding to some large side chains, Cu ion pairs, and interaction networks of adjacent subunits. A FU topology path intertwining between the two subunits of the asymmetric unit is unambiguously determined. Our observations suggest a structural mechanism for the stability of the entire hemocyanin didecamer and 20 "communication clusters" across asymmetric units responsible for its allosteric property upon oxygen binding.
 
Cryo-EM Structure of a Molluscan Hemocyanin Suggests Its Allosteric Mechanism.,Zhang Q, Dai X, Cong Y, Zhang J, Chen DH, Dougherty MT, Wang J, Ludtke SJ, Schmid MF, Chiu W Structure. 2013 Mar 26. pii: S0969-2126(13)00075-0. doi:, 10.1016/j.str.2013.02.018. PMID:23541894<ref>PMID:23541894</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3j32" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</SX>
</SX>
[[Category: Haliotis diversicolor]]
[[Category: Haliotis diversicolor]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Chen, D H]]
[[Category: Chen D-H]]
[[Category: Chiu, W]]
[[Category: Chiu W]]
[[Category: Cong, Y]]
[[Category: Cong Y]]
[[Category: Dai, X]]
[[Category: Dai X]]
[[Category: Dougherty, M]]
[[Category: Dougherty M]]
[[Category: Ludtke, S]]
[[Category: Ludtke S]]
[[Category: Schmid, M F]]
[[Category: Schmid MF]]
[[Category: Wang, J]]
[[Category: Wang J]]
[[Category: Zhang, J]]
[[Category: Zhang J]]
[[Category: Zhang, Q]]
[[Category: Zhang Q]]
[[Category: Allosteric]]
[[Category: Oxygen transport]]
Retrieved from "https://proteopedia.org/3j32"