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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3j35]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J35 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J35 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3j35]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J35 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J35 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j35 OCA], [https://pdbe.org/3j35 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j35 RCSB], [https://www.ebi.ac.uk/pdbsum/3j35 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j35 ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 35&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j35 OCA], [https://pdbe.org/3j35 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j35 RCSB], [https://www.ebi.ac.uk/pdbsum/3j35 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j35 ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/E7FLK7_9FLAV E7FLK7_9FLAV]
We report on a conformational transition of dengue virus when changing the temperature from that present in its mosquito vectors to that of its human host. Using cryoelectron microscopy, we show that although the virus has a smooth surface, a diameter of approximately 500 A, and little exposed membrane at room temperature, the virions have a bumpy appearance with a diameter of approximately 550 A and some exposed membrane at 37 degrees C. The bumpy structure at 37 degrees C was found to be similar to the previously predicted structure of an intermediate between the smooth mature and fusogenic forms. As humans have a body temperature of 37 degrees C, the bumpy form of the virus would be the form present in humans. Thus, optimal dengue virus vaccines should induce antibodies that preferentially recognize epitopes exposed on the bumpy form of the virus.
 
Dengue structure differs at the temperatures of its human and mosquito hosts.,Zhang X, Sheng J, Plevka P, Kuhn RJ, Diamond MS, Rossmann MG Proc Natl Acad Sci U S A. 2013 Apr 8. PMID:23569243<ref>PMID:23569243</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3j35" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</SX>
</SX>
[[Category: Dengue virus 2]]
[[Category: Dengue virus 2]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Diamond, M S]]
[[Category: Diamond MS]]
[[Category: Kuhn, R J]]
[[Category: Kuhn RJ]]
[[Category: Plevka, P]]
[[Category: Plevka P]]
[[Category: Rossmann, M G]]
[[Category: Rossmann MG]]
[[Category: Sheng, J]]
[[Category: Sheng J]]
[[Category: Zhang, X Z]]
[[Category: Zhang XZ]]
[[Category: Bumpy structure]]
[[Category: Conformational change]]
[[Category: Temperature dependent]]
[[Category: Virus]]

Latest revision as of 10:09, 21 February 2024

Cryo-EM reconstruction of Dengue virus at 37 C

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