7zm6: Difference between revisions
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The entry | ==Nariva virus receptor binding protein== | ||
<StructureSection load='7zm6' size='340' side='right'caption='[[7zm6]], [[Resolution|resolution]] 2.07Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7zm6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Narmovirus_narivaense Narmovirus narivaense]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZM6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZM6 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.07Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zm6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zm6 OCA], [https://pdbe.org/7zm6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zm6 RCSB], [https://www.ebi.ac.uk/pdbsum/7zm6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zm6 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/B8XH64_9MONO B8XH64_9MONO] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Genetically diverse paramyxoviruses are united in their presentation of a receptor-binding protein (RBP), which works in concert with the fusion protein to facilitate host-cell entry. The C-terminal head region of the paramyxoviral RBP, a primary determinant of host-cell tropism and inter-species transmission potential, forms structurally distinct classes dependent upon protein and glycan receptor specificity. Here, we reveal the architecture of the C-terminal head region of the RBPs from Nariva virus (NarV) and Mossman virus (MosV), two archetypal rodent-borne paramyxoviruses within the recently established genus Narmovirus, family Paramyxoviridae. Our analysis reveals that while narmoviruses retain the general architectural features associated with paramyxoviral RBPs, namely, a six-bladed beta-propeller fold, they lack the structural motifs associated with known receptor-mediated host-cell entry pathways. This investigation indicates that the RBPs of narmoviruses exhibit pathobiological features that are distinct from those of other paramyxoviruses. | |||
Crystal structure and solution state of the C-terminal head region of the narmovirus receptor binding protein.,Stelfox AJ, Oguntuyo KY, Rissanen I, Harlos K, Rambo R, Lee B, Bowden TA mBio. 2023 Oct 31;14(5):e0139123. doi: 10.1128/mbio.01391-23. Epub 2023 Sep 22. PMID:37737607<ref>PMID:37737607</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 7zm6" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Narmovirus narivaense]] | |||
[[Category: Bowden TA]] | |||
[[Category: Lee B]] | |||
[[Category: Rambo R]] | |||
[[Category: Rissanen I]] | |||
[[Category: Stelfox AJ]] | |||
Latest revision as of 09:44, 9 October 2024
Nariva virus receptor binding protein
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