3o6q: Difference between revisions

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<StructureSection load='3o6q' size='340' side='right'caption='[[3o6q]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='3o6q' size='340' side='right'caption='[[3o6q]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3o6q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O6Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O6Q FirstGlance]. <br>
<table><tr><td colspan='2'>[[3o6q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O6Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O6Q FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BSU12830, spoIISA, ykaC ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835]), BSU12820, spoIISB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o6q OCA], [https://pdbe.org/3o6q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o6q RCSB], [https://www.ebi.ac.uk/pdbsum/3o6q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o6q ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o6q OCA], [https://pdbe.org/3o6q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o6q RCSB], [https://www.ebi.ac.uk/pdbsum/3o6q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o6q ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/SP2SA_BACSU SP2SA_BACSU]] Toxic component of a toxin-antitoxin (TA) module. Its toxic activity is neutralized by cognate antitoxin SpoIISB. Expression in the absence of SpoIISB permits sporulation to stage II, when plasmolysis zones and holes in the peptidoglycan layer are observed, resulting in cell death. Lethal when synthesized during vegetative growth in the absence of SpoIISB. In E.coli both the membrane bound and soluble domain are required in cis for toxin activity.<ref>PMID:11371520</ref> [[https://www.uniprot.org/uniprot/SP2SB_BACSU SP2SB_BACSU]] Antitoxin component of a toxin-antitoxin (TA) module. Antitoxin that binds cognate toxin SpoIISA and neutralizes its toxic activity; unlike most antitoxins it does not seem to be highly labile upon expression in E.coli.<ref>PMID:11371520</ref> 
[https://www.uniprot.org/uniprot/SP2SA_BACSU SP2SA_BACSU] Toxic component of a toxin-antitoxin (TA) module. Its toxic activity is neutralized by cognate antitoxin SpoIISB. Expression in the absence of SpoIISB permits sporulation to stage II, when plasmolysis zones and holes in the peptidoglycan layer are observed, resulting in cell death. Lethal when synthesized during vegetative growth in the absence of SpoIISB. In E.coli both the membrane bound and soluble domain are required in cis for toxin activity.<ref>PMID:11371520</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Vibrio subtilis ehrenberg 1835]]
[[Category: Bacillus subtilis]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Barak, I]]
[[Category: Barak I]]
[[Category: Blagova, E V]]
[[Category: Blagova EV]]
[[Category: Florek, P]]
[[Category: Florek P]]
[[Category: Lebedev, A A]]
[[Category: Lebedev AA]]
[[Category: Levdikov, V M]]
[[Category: Levdikov VM]]
[[Category: Wilkinson, A J]]
[[Category: Wilkinson AJ]]
[[Category: Gaf domain]]
[[Category: Sporulation]]
[[Category: Toxin - antitoxin complex]]
[[Category: Toxin-antitoxin]]
[[Category: Toxin-antitoxin complex]]
Retrieved from "https://proteopedia.org/3o6q"