3p3l: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
 
(One intermediate revision by the same user not shown)
Line 3: Line 3:
<StructureSection load='3p3l' size='340' side='right'caption='[[3p3l]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='3p3l' size='340' side='right'caption='[[3p3l]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3p3l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"streptomyces_thioluteus"_okami_1952 "streptomyces thioluteus" okami 1952]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P3L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P3L FirstGlance]. <br>
<table><tr><td colspan='2'>[[3p3l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_thioluteus Streptomyces thioluteus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P3L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P3L FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3p3o|3p3o]], [[3p3x|3p3x]], [[3p3z|3p3z]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">aurH ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=66431 "Streptomyces thioluteus" Okami 1952])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p3l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p3l OCA], [https://pdbe.org/3p3l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p3l RCSB], [https://www.ebi.ac.uk/pdbsum/3p3l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p3l ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p3l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p3l OCA], [https://pdbe.org/3p3l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p3l RCSB], [https://www.ebi.ac.uk/pdbsum/3p3l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p3l ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/AURH_STRTU AURH_STRTU] Bifunctional cytochrome P450 protein involved in the biosynthesis of the antibiotic aureothin, a nitroaryl polyketide metabolite with antifungal, cytotoxic and insecticidal activities (PubMed:15612710, PubMed:18855960). Catalyzes the hydroxylation of luteothin (also called deoxyaureothin), leading to the formation of the intermediate (7R)-7-hydroxydeoxyaureothin, followed by the formation of the aureothin tetrahydrofuran ring, the final step in the biosynthesis of aureothin (PubMed:15612710, PubMed:18855960, PubMed:21280577).<ref>PMID:15612710</ref> <ref>PMID:18855960</ref> <ref>PMID:21280577</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 25: Line 26:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Streptomyces thioluteus okami 1952]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Hertweck, C]]
[[Category: Streptomyces thioluteus]]
[[Category: Mueller, U]]
[[Category: Hertweck C]]
[[Category: Richter, M E.A]]
[[Category: Mueller U]]
[[Category: Zocher, G]]
[[Category: Richter MEA]]
[[Category: Cytochrome p450]]
[[Category: Zocher G]]
[[Category: Monooxygenase]]
[[Category: Oxidoreductase]]
Retrieved from "https://proteopedia.org/3p3l"