3p76: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3p76]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P76 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P76 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3p76]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P76 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P76 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=P76:N-[(1S,2R)-2-HYDROXY-1-(HYDROXYCARBAMOYL)PROPYL]-4-[4-(PHENYLETHYNYL)PHENYL]PIPERIDINE-1-CARBOXAMIDE'>P76</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.93&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=P76:N-[(1S,2R)-2-HYDROXY-1-(HYDROXYCARBAMOYL)PROPYL]-4-[4-(PHENYLETHYNYL)PHENYL]PIPERIDINE-1-CARBOXAMIDE'>P76</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p76 OCA], [https://pdbe.org/3p76 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p76 RCSB], [https://www.ebi.ac.uk/pdbsum/3p76 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p76 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p76 OCA], [https://pdbe.org/3p76 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p76 RCSB], [https://www.ebi.ac.uk/pdbsum/3p76 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p76 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/LPXC_AQUAE LPXC_AQUAE]] Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity).  
[https://www.uniprot.org/uniprot/LPXC_AQUAE LPXC_AQUAE] Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity).
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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[[Category: Aquifex aeolicus]]
[[Category: Aquifex aeolicus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Orth, P]]
[[Category: Orth P]]
[[Category: Amidohydrolase]]
[[Category: Amino acid motif]]
[[Category: Binding site]]
[[Category: Drug design]]
[[Category: Enzyme inhibitor]]
[[Category: Escherichia coli protein]]
[[Category: Hydrolase]]
[[Category: Hydrophobicity]]
[[Category: Lipid some]]
[[Category: Protein conformation]]
[[Category: Protein folding]]
[[Category: Recombinant fusion protein]]
[[Category: Structure-activity relationship]]

Latest revision as of 09:49, 6 September 2023

X-ray crystal structure of Aquifex aeolicus LpxC complexed SCH1379777

3p76, resolution 1.93Å

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