7zw4: Difference between revisions
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==Crystal structure of Talin R7R8 domains with Caskin-2 LD-peptide== | |||
<StructureSection load='7zw4' size='340' side='right'caption='[[7zw4]], [[Resolution|resolution]] 2.72Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7zw4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZW4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZW4 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.72Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zw4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zw4 OCA], [https://pdbe.org/7zw4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zw4 RCSB], [https://www.ebi.ac.uk/pdbsum/7zw4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zw4 ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Talin (herein referring collectively to talin 1 and 2) couples the actomyosin cytoskeleton to integrins and transmits tension to the extracellular matrix. Talin also interacts with numerous additional proteins capable of modulating the actin-integrin linkage and thus downstream mechanosignaling cascades. Here, we demonstrate that the scaffold protein Caskin2 interacts directly with the R8 domain of talin through its C-terminal LD motif. Caskin2 also associates with the WAVE regulatory complex to promote cell migration in an Abi1-dependent manner. Furthermore, we demonstrate that the Caskin2-Abi1 interaction is regulated by growth factor-induced phosphorylation of Caskin2 on serine 878. In MCF7 and UACC893 cells, which contain an amplification of CASKIN2, Caskin2 localizes in plasma membrane-associated plaques and around focal adhesions in cortical microtubule stabilization complexes. Taken together, our results identify Caskin2 as a novel talin-binding protein that might not only connect integrin-mediated adhesion to actin polymerization but could also play a role in crosstalk between integrins and microtubules. | |||
Caskin2 is a novel talin- and Abi1-binding protein that promotes cell motility.,Wang W, Atherton P, Kreft M, Te Molder L, van der Poel S, Hoekman L, Celie P, Joosten RP, Fassler R, Perrakis A, Sonnenberg A J Cell Sci. 2024 May 1;137(9):jcs262116. doi: 10.1242/jcs.262116. Epub 2024 May , 16. PMID:38587458<ref>PMID:38587458</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 7zw4" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Talin 3D structures|Talin 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Celie PHN]] | |||
[[Category: Joosten RP]] | |||
[[Category: Perrakis A]] | |||
[[Category: Sonnenberg A]] | |||
Latest revision as of 05:16, 12 June 2024
Crystal structure of Talin R7R8 domains with Caskin-2 LD-peptide
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