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<StructureSection load='3prp' size='340' side='right'caption='[[3prp]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='3prp' size='340' side='right'caption='[[3prp]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3prp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/ ] and [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PRP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PRP FirstGlance]. <br>
<table><tr><td colspan='2'>[[3prp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Orthonairovirus_haemorrhagiae Orthonairovirus haemorrhagiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PRP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PRP FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3CN:3-AMINOPROPANE'>3CN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.699&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3prm|3prm]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4LJ:1.7.6+3-BROMANYLPROPAN-1-AMINE'>4LJ</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">UBC ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Ubiquitinyl_hydrolase_1 Ubiquitinyl hydrolase 1], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.12 3.4.19.12] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3prp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3prp OCA], [https://pdbe.org/3prp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3prp RCSB], [https://www.ebi.ac.uk/pdbsum/3prp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3prp ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3prp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3prp OCA], [https://pdbe.org/3prp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3prp RCSB], [https://www.ebi.ac.uk/pdbsum/3prp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3prp ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/L_CCHFI L_CCHFI] Displays RNA-directed RNA polymerase, deubiquitinating and deISGylase activities. RNA-dependent RNA polymerase is responsible for replication and transcription of the viral RNA genome. The deubiquitinating activity cleaves both ubiquitinated and ISGylated products and may therefore regulate ubiquitin and ISG15 dependent innate immunity.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Ubiquitinyl hydrolase 1]]
[[Category: Orthonairovirus haemorrhagiae]]
[[Category: Baker, E A]]
[[Category: Baker EA]]
[[Category: Brunzelle, J S]]
[[Category: Brunzelle JS]]
[[Category: Capodagli, G C]]
[[Category: Capodagli GC]]
[[Category: Masters, E M]]
[[Category: Masters EM]]
[[Category: McKercher, M A]]
[[Category: McKercher MA]]
[[Category: Pegan, S D]]
[[Category: Pegan SD]]
[[Category: Cysteine protease]]
[[Category: Deubiquitinase]]
[[Category: Hydrolase]]
[[Category: Hydrolase-hydrolase complex]]
[[Category: Ubiquitin hydrolase]]
[[Category: Viral protein]]
Retrieved from "https://proteopedia.org/3prp"