7xyt: Difference between revisions
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New page: '''Unreleased structure''' The entry 7xyt is ON HOLD Authors: Dong, C., Yan, X., Li, Y. Description: Crystal structure of X2A Category: Unreleased Structures Category: Yan, X [... |
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==Crystal structure of ZER1 bound to AFLH degron== | |||
<StructureSection load='7xyt' size='340' side='right'caption='[[7xyt]], [[Resolution|resolution]] 1.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7xyt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XYT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XYT FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xyt OCA], [https://pdbe.org/7xyt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xyt RCSB], [https://www.ebi.ac.uk/pdbsum/7xyt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xyt ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Dong | == Function == | ||
[[Category: Li | [https://www.uniprot.org/uniprot/ZER1_HUMAN ZER1_HUMAN] Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC (PubMed:17304241, PubMed:31273098). Acts redudantly with ZYG11B to target substrates bearing N-terminal glycine degrons for proteasomal degradation (PubMed:33093214). Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites. Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N-myristoylation (PubMed:31273098).<ref>PMID:17304241</ref> <ref>PMID:31273098</ref> <ref>PMID:33093214</ref> | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Dong C]] | |||
[[Category: Li Y]] | |||
[[Category: Yan X]] | |||
Latest revision as of 09:39, 14 February 2024
Crystal structure of ZER1 bound to AFLH degron
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