8a07: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 8a07 is ~~ON HOLD~~

==MTH1 in complex with TH001969==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[8a07]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8A07 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=8A07 FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.19Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=L3N:1~{H}-quinazoline-2,4-dione'>L3N</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=8a07 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a07 OCA], [https://pdbe.org/8a07 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a07 RCSB], [https://www.ebi.ac.uk/pdbsum/8a07 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a07 ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Narwal M]]

[[Category: Scaletti ER]]

[[Category: Stenmark P]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8a07 is ON HOLD
+==MTH1 in complex with TH001969==
+<StructureSection load='8a07' size='340' side='right'caption='[[8a07]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8a07]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8A07 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8A07 FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.19&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=L3N:1~{H}-quinazoline-2,4-dione'>L3N</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a07 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a07 OCA], [https://pdbe.org/8a07 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a07 RCSB], [https://www.ebi.ac.uk/pdbsum/8a07 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a07 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Narwal M]]
+[[Category: Scaletti ER]]
+[[Category: Stenmark P]]