8cz8: Difference between revisions
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==Novel Anti-Mesothelin Antibodies Enable Crystallography of the Intact Mesothelin Ectodo- main and Engineering of Potent, T cell-engaging Bispecific Therapeutics== | |||
<StructureSection load='8cz8' size='340' side='right'caption='[[8cz8]], [[Resolution|resolution]] 2.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8cz8]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CZ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CZ8 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8cz8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8cz8 OCA], [https://pdbe.org/8cz8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8cz8 RCSB], [https://www.ebi.ac.uk/pdbsum/8cz8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8cz8 ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/MSLN_HUMAN MSLN_HUMAN] Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/MSLN_HUMAN MSLN_HUMAN] Membrane-anchored forms may play a role in cellular adhesion.<ref>PMID:8288629</ref> <ref>PMID:14676194</ref> Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.<ref>PMID:8288629</ref> <ref>PMID:14676194</ref> | |||
==See Also== | |||
*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Bandaranayake AD]] | ||
[[Category: | [[Category: Carter J]] | ||
[[Category: | [[Category: Chan MK]] | ||
[[Category: | [[Category: Clarke M]] | ||
[[Category: | [[Category: Correnti CE]] | ||
[[Category: | [[Category: Friend DJ]] | ||
[[Category: | [[Category: Lin I]] | ||
[[Category: | [[Category: Mehlin C]] | ||
[[Category: | [[Category: Meshinchi S]] | ||
[[Category: | [[Category: Olson JM]] | ||
[[Category: Pilat K]] | |||
[[Category: Ruff RO]] | |||
[[Category: Rupert PB]] | |||
[[Category: Strong RK]] | |||
Latest revision as of 10:04, 25 October 2023
Novel Anti-Mesothelin Antibodies Enable Crystallography of the Intact Mesothelin Ectodo- main and Engineering of Potent, T cell-engaging Bispecific Therapeutics
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