7v62: Difference between revisions
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==Crystal structure of human OSBP ORD in complex with cholesterol== | ==Crystal structure of human OSBP ORD in complex with cholesterol== | ||
<StructureSection load='7v62' size='340' side='right'caption='[[7v62]]' scene=''> | <StructureSection load='7v62' size='340' side='right'caption='[[7v62]], [[Resolution|resolution]] 3.25Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7V62 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7V62 FirstGlance]. <br> | <table><tr><td colspan='2'>[[7v62]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7V62 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7V62 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7v62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7v62 OCA], [https://pdbe.org/7v62 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7v62 RCSB], [https://www.ebi.ac.uk/pdbsum/7v62 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7v62 ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.25Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7v62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7v62 OCA], [https://pdbe.org/7v62 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7v62 RCSB], [https://www.ebi.ac.uk/pdbsum/7v62 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7v62 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/OSBP1_HUMAN OSBP1_HUMAN] Binds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25-hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability.<ref>PMID:15746430</ref> <ref>PMID:18450749</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Kato R]] | [[Category: Kato R]] | ||
[[Category: Kobayashi J]] | [[Category: Kobayashi J]] | ||
Latest revision as of 05:56, 17 September 2025
Crystal structure of human OSBP ORD in complex with cholesterol
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