3qkv: Difference between revisions

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<StructureSection load='3qkv' size='340' side='right'caption='[[3qkv]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
<StructureSection load='3qkv' size='340' side='right'caption='[[3qkv]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3qkv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QKV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QKV FirstGlance]. <br>
<table><tr><td colspan='2'>[[3qkv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QKV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QKV FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QKV:(6-BROMO-1H,4H-SPIRO[1,3-BENZODIOXINE-2,4-PIPERIDIN]-1-YL)METHANOL'>QKV</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3qj8|3qj8]], [[3qj9|3qj9]], [[3qk5|3qk5]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QKV:(6-BROMO-1H,4H-SPIRO[1,3-BENZODIOXINE-2,4-PIPERIDIN]-1-YL)METHANOL'>QKV</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Faah, Faah1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Fatty_acid_amide_hydrolase Fatty acid amide hydrolase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.99 3.5.1.99] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qkv OCA], [https://pdbe.org/3qkv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qkv RCSB], [https://www.ebi.ac.uk/pdbsum/3qkv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qkv ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qkv OCA], [https://pdbe.org/3qkv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qkv RCSB], [https://www.ebi.ac.uk/pdbsum/3qkv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qkv ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/FAAH1_RAT FAAH1_RAT]] Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity).  
[https://www.uniprot.org/uniprot/FAAH1_RAT FAAH1_RAT] Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Buffalo rat]]
[[Category: Fatty acid amide hydrolase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Min, X]]
[[Category: Rattus norvegicus]]
[[Category: Walker, N P.C]]
[[Category: Min X]]
[[Category: Wang, Z]]
[[Category: Walker NPC]]
[[Category: Faah]]
[[Category: Wang Z]]
[[Category: Fatty-acid amide hydrolase]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Protein-inhibitor complex]]
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