7q7v: Difference between revisions
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==Crystal structure of human BCL6 BTB domain in complex with compound 12a== | ==Crystal structure of human BCL6 BTB domain in complex with compound 12a== | ||
<StructureSection load='7q7v' size='340' side='right'caption='[[7q7v]]' scene=''> | <StructureSection load='7q7v' size='340' side='right'caption='[[7q7v]], [[Resolution|resolution]] 1.81Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q7V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q7V FirstGlance]. <br> | <table><tr><td colspan='2'>[[7q7v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q7V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q7V FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q7v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q7v OCA], [https://pdbe.org/7q7v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q7v RCSB], [https://www.ebi.ac.uk/pdbsum/7q7v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q7v ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.81Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9GR:2-chloranyl-4-[[(2R)-2-cyclopropyl-7-methyl-6-oxidanylidene-1,2,3,4-tetrahydro-[1,4]oxazepino[2,3-c]quinolin-10-yl]amino]pyridine-3-carbonitrile'>9GR</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q7v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q7v OCA], [https://pdbe.org/7q7v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q7v RCSB], [https://www.ebi.ac.uk/pdbsum/7q7v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q7v ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | |||
[https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.<ref>PMID:9649500</ref> <ref>PMID:18280243</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Le Bihan Y-V]] | [[Category: Le Bihan Y-V]] | ||
[[Category: Rodrigues MJ]] | [[Category: Rodrigues MJ]] | ||
[[Category: Van Montfort RLM]] | [[Category: Van Montfort RLM]] | ||
Latest revision as of 13:15, 1 February 2024
Crystal structure of human BCL6 BTB domain in complex with compound 12a
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