7r2e: Difference between revisions
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==Structure of human Senp7 with SUMO2== | |||
<StructureSection load='7r2e' size='340' side='right'caption='[[7r2e]], [[Resolution|resolution]] 1.74Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7r2e]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R2E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R2E FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AYE:PROP-2-EN-1-AMINE'>AYE</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r2e OCA], [https://pdbe.org/7r2e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r2e RCSB], [https://www.ebi.ac.uk/pdbsum/7r2e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r2e ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SUMO3_HUMAN SUMO3_HUMAN] Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4.<ref>PMID:11451954</ref> <ref>PMID:18538659</ref> | |||
==See Also== | |||
*[[SUMO 3D Structures|SUMO 3D Structures]] | |||
*[[Sentrin-specific protease|Sentrin-specific protease]] | |||
[[Category: | == References == | ||
[[Category: Li | <references/> | ||
[[Category: Reverter | __TOC__ | ||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Li Y]] | |||
[[Category: Reverter D]] | |||
Latest revision as of 07:59, 7 February 2024
Structure of human Senp7 with SUMO2
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