7y39: Difference between revisions
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==Ubiquitin-like domain of human ZFAND1== | |||
<StructureSection load='7y39' size='340' side='right'caption='[[7y39]], [[Resolution|resolution]] 1.88Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7y39]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Y39 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Y39 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.88Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7y39 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7y39 OCA], [https://pdbe.org/7y39 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7y39 RCSB], [https://www.ebi.ac.uk/pdbsum/7y39 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7y39 ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/ZFAN1_HUMAN ZFAN1_HUMAN] Plays a role in the regulation of cytoplasmic stress granules (SGs) turnover. SGs are dynamic and transient cytoplasmic ribonucleoprotein assemblies important for cellular protein homeostasis when protein production is suspended after acute exogenous stress (PubMed:29804830). Associates with SGs and is involved in the efficient and specific arsenite-induced clearance process of SGs through the recruitment of the ubiquitin-selective ATPase VCP and the 26S proteasome (PubMed:29804830). This process requires both complexes for efficient degradation of damaged ubiquitinated SG proteins during recovery from arsenite stress, and hence avoiding aberrant cytoplasmic SGs degradation via autophagy (PubMed:29804830).<ref>PMID:29804830</ref> | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Chang CF]] | |||
[[Category: Draczkowski P]] | |||
[[Category: Fan PJ]] | |||
[[Category: Hsu STD]] | |||
[[Category: Ko KT]] | |||
[[Category: Lai CH]] | |||
[[Category: Yu TA]] | |||
Latest revision as of 07:23, 3 April 2024
Ubiquitin-like domain of human ZFAND1
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