2mj9: Difference between revisions
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==Designed Exendin-4 analogues== | ==Designed Exendin-4 analogues== | ||
<StructureSection load='2mj9' size='340' side='right'caption='[[2mj9 | <StructureSection load='2mj9' size='340' side='right'caption='[[2mj9]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2mj9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2mj9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Heloderma_suspectum Heloderma suspectum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MJ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MJ9 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DAL:D-ALANINE'>DAL</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mj9 OCA], [https://pdbe.org/2mj9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mj9 RCSB], [https://www.ebi.ac.uk/pdbsum/2mj9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mj9 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mj9 OCA], [https://pdbe.org/2mj9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mj9 RCSB], [https://www.ebi.ac.uk/pdbsum/2mj9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mj9 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/EXE4_HELSU EXE4_HELSU] Venom protein that mimics the incretin hormone glucagon-like peptide 1 (GLP-1). It stimulates insulin synthesis and secretion, protects against beta-cell apoptosis in response to different insults, and promotes beta-cell proliferation. It also promotes satiety, reduces food intake, reduces fat deposition, reduces body weight and inhibits gastric emptying. Interacts with GLP-1 receptor (GLP1R). Induces hypotension that is mediated by relaxation of cardiac smooth muscle.<ref>PMID:8405712</ref> <ref>PMID:19837656</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Heloderma suspectum]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Farkas | [[Category: Farkas V]] | ||
[[Category: Hegyi | [[Category: Hegyi O]] | ||
[[Category: Jermendy | [[Category: Jermendy A]] | ||
[[Category: Perczel | [[Category: Perczel A]] | ||
[[Category: Rovo | [[Category: Rovo P]] | ||
[[Category: Straner | [[Category: Straner P]] | ||
[[Category: Szabo | [[Category: Szabo M]] | ||
[[Category: Toth | [[Category: Toth GK]] | ||
