3t5b: Difference between revisions

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<StructureSection load='3t5b' size='340' side='right'caption='[[3t5b]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
<StructureSection load='3t5b' size='340' side='right'caption='[[3t5b]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3t5b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T5B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T5B FirstGlance]. <br>
<table><tr><td colspan='2'>[[3t5b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T5B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T5B FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3t5a|3t5a]], [[3t5c|3t5c]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">fadD13, MT3174, Rv3089 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t5b OCA], [https://pdbe.org/3t5b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t5b RCSB], [https://www.ebi.ac.uk/pdbsum/3t5b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t5b ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t5b OCA], [https://pdbe.org/3t5b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t5b RCSB], [https://www.ebi.ac.uk/pdbsum/3t5b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t5b ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/FAC13_MYCTU FAC13_MYCTU]] Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. Catalyzes the activation of long-chain fatty acids as acyl-coenzyme A (acyl-CoA), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension. It has preference for the fatty acid with long chain length in the following order: hexacosanoic acid (C26), tetracosanoic acid (C24) and palmitic acid (C16).<ref>PMID:15937179</ref> <ref>PMID:20027301</ref> <ref>PMID:22560731</ref> 
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Myctu]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Goyal, A]]
[[Category: Goyal A]]
[[Category: Sankaranarayanan, R]]
[[Category: Sankaranarayanan R]]
[[Category: Acetyl-coa synthetase like fold]]
[[Category: Amp-binding]]
[[Category: Ligase]]

Latest revision as of 17:28, 1 November 2023

Crystal structure of N-terminal domain of FACL13 from Mycobacterium tuberculosis

3t5b, resolution 2.35Å

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