Gasdermin: Difference between revisions

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'''Gasdermin''' (GSDM)  is the substrate of the inflammatory [[Caspase]] downstream from inflammasomes which activate caspase.  Inflammasomes are supramolecular signalling  assemblies activating the lytic process against exogenous pathogens. GSDM is required for cytokine release and pyroptosis, a lytic form of programmed cell death) <ref>PMID:31451512</ref>.  Pyropptosis is the regulated lytic cell death mediated by GSMD pore formation.  GSDM D contains 2 domains: the N-terminal fragment which is pore-forming and the repressive C-terminal.  The GSDM family contains 6 members in human.  
'''Gasdermin''' (GSDM)  is the substrate of the inflammatory [[Caspase]] downstream from inflammasomes which activate caspase.  Inflammasomes are supramolecular signalling  assemblies activating the lytic process against exogenous pathogens. GSDM is required for cytokine release and pyroptosis, a lytic form of programmed cell death) <ref>PMID:31451512</ref>.  Pyropptosis is the regulated lytic cell death mediated by GSMD pore formation.  GSDM D contains 2 domains: the N-terminal fragment which is pore-forming and the repressive C-terminal.  The GSDM family contains 6 members in human.  
*'''Gasdermin B''' has a role in antibacterial defense, inflammatory pathologies and cancer<ref>PMID:37997534</ref>.
*'''Gasdermin D''' is a pore-forming protein involved in cell death of macrophages<ref>PMID:32800355</ref>.


== Disease ==
== Disease ==
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== Structural highlights ==
== Structural highlights ==


This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
The 3D structure of GSDM A3 shows the monomer of the pore formed by the N-terminal of the molecule.  Each subunit contributes 4 long β strands to the transmembrane region of the pore.  The pore is formed by 27-fold symmetry<ref>PMID:29695864</ref>.  
 
==3D structures of gasdermin==
 
[[Gasdermin 3D structures]]


</StructureSection>
</StructureSection>
== References ==
== References ==
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[[Category:Topic Page]]
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