1fn7: Difference between revisions

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New page: left|200px<br /> <applet load="1fn7" size="450" color="white" frame="true" align="right" spinBox="true" caption="1fn7, resolution 2.60Å" /> '''COUPLING OF DAMAGE ...
 
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[[Image:1fn7.gif|left|200px]]<br />
<applet load="1fn7" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1fn7, resolution 2.60&Aring;" />
'''COUPLING OF DAMAGE RECOGNITION AND CATALYSIS BY A HUMAN BASE-EXCISION DNA REPAIR PROTEIN'''<br />


==Disease==
==COUPLING OF DAMAGE RECOGNITION AND CATALYSIS BY A HUMAN BASE-EXCISION DNA REPAIR PROTEIN==
Known disease associated with this structure: Renal cell carcinoma, clear cell, somatic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601982 601982]]
<StructureSection load='1fn7' size='340' side='right'caption='[[1fn7]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1fn7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FN7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FN7 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3DR:1,2-DIDEOXYRIBOFURANOSE-5-PHOSPHATE'>3DR</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fn7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fn7 OCA], [https://pdbe.org/1fn7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fn7 RCSB], [https://www.ebi.ac.uk/pdbsum/1fn7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fn7 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/OGG1_HUMAN OGG1_HUMAN] Defects in OGG1 may be a cause of renal cell carcinoma (RCC) [MIM:[https://omim.org/entry/144700 144700]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.
== Function ==
[https://www.uniprot.org/uniprot/OGG1_HUMAN OGG1_HUMAN] DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fn/1fn7_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fn7 ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
1FN7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1FN7 OCA].
*[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
Coupling of substrate recognition and catalysis by a human base-excision DNA repair protein., Norman DP, Bruner SD, Verdine GL, J Am Chem Soc. 2001 Jan 17;123(2):359-60. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11456534 11456534]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Bruner, S.D.]]
[[Category: Bruner SD]]
[[Category: Norman, D.P.G.]]
[[Category: Norman DPG]]
[[Category: Verdine, G.L.]]
[[Category: Verdine GL]]
[[Category: CA]]
[[Category: ap lyase]]
[[Category: base flipping]]
[[Category: base recognition]]
[[Category: base-exicision repair]]
[[Category: dna glycosidase]]
[[Category: dna glycosylase]]
[[Category: dna repair]]
[[Category: extrahelical dna]]
[[Category: flipped-out base]]
[[Category: helix hairpin helix]]
[[Category: hydroxyguanine]]
[[Category: mechanism-based inhibitor]]
[[Category: oxoguanine]]
[[Category: protein/dna]]
 
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Retrieved from "https://proteopedia.org/1fn7"