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New page: left|200px<br /> <applet load="1fnl" size="450" color="white" frame="true" align="right" spinBox="true" caption="1fnl, resolution 1.8Å" /> '''CRYSTAL STRUCTURE OF...
 
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[[Image:1fnl.gif|left|200px]]<br />
<applet load="1fnl" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1fnl, resolution 1.8&Aring;" />
'''CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF A HUMAN FCGRIII'''<br />


==Overview==
==CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF A HUMAN FCGRIII==
Fc receptors play a major role in immune defenses against pathogens and in, inflammatory processes. The crystal structure of a human immunoglobulin, receptor, FcgammaRIIIb, has been determined to 1.8 A resolution. The, overall fold consists of two immunoglobulin-like domains with an acute, interdomain hinge angle of approximately 50 degrees. Trp-113, wedged, between the N-terminal D1 and the C-terminal D2 domains, appears to, further restrict the hinge angle. The putative Fc binding region of the, receptor carries a net positive charge complementary to the, negative-charged receptor binding regions on Fc. A 1:1 binding, stoichiometry between the receptor and Fc was measured by both the, equilibrium and nonequilibrium size-exclusion chromatography. Two separate, parallel dimers are observed in the crystal lattice, offering intriguing, models for receptor aggregation.
<StructureSection load='1fnl' size='340' side='right'caption='[[1fnl]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1fnl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FNL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FNL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fnl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fnl OCA], [https://pdbe.org/1fnl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fnl RCSB], [https://www.ebi.ac.uk/pdbsum/1fnl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fnl ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FCG3B_HUMAN FCG3B_HUMAN] Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fn/1fnl_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fnl ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Fc receptors play a major role in immune defenses against pathogens and in inflammatory processes. The crystal structure of a human immunoglobulin receptor, FcgammaRIIIb, has been determined to 1.8 A resolution. The overall fold consists of two immunoglobulin-like domains with an acute interdomain hinge angle of approximately 50 degrees. Trp-113, wedged between the N-terminal D1 and the C-terminal D2 domains, appears to further restrict the hinge angle. The putative Fc binding region of the receptor carries a net positive charge complementary to the negative-charged receptor binding regions on Fc. A 1:1 binding stoichiometry between the receptor and Fc was measured by both the equilibrium and nonequilibrium size-exclusion chromatography. Two separate parallel dimers are observed in the crystal lattice, offering intriguing models for receptor aggregation.


==Disease==
Crystal structure of the extracellular domain of a human Fc gamma RIII.,Zhang Y, Boesen CC, Radaev S, Brooks AG, Fridman WH, Sautes-Fridman C, Sun PD Immunity. 2000 Sep;13(3):387-95. PMID:11021536<ref>PMID:11021536</ref>
Known diseases associated with this structure: Lupus erythematosus, systemic, susceptibility OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=146740 146740]], Neutropenia, alloimmune neonatal OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=146740 146740]], Viral infections, recurrent OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=146740 146740]]


==About this Structure==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
1FNL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with HG as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1FNL OCA].
</div>
 
<div class="pdbe-citations 1fnl" style="background-color:#fffaf0;"></div>
==Reference==
== References ==
Crystal structure of the extracellular domain of a human Fc gamma RIII., Zhang Y, Boesen CC, Radaev S, Brooks AG, Fridman WH, Sautes-Fridman C, Sun PD, Immunity. 2000 Sep;13(3):387-95. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11021536 11021536]
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Boesen, C.C.]]
[[Category: Boesen CC]]
[[Category: Brooks, A.G.]]
[[Category: Brooks AG]]
[[Category: Fridman, W.H.]]
[[Category: Fridman WH]]
[[Category: Radaev, S.]]
[[Category: Radaev S]]
[[Category: Sautes-Fridman, C.]]
[[Category: Sautes-Fridman C]]
[[Category: Sun, P.D.]]
[[Category: Sun PD]]
[[Category: Zhang, Y.]]
[[Category: Zhang Y]]
[[Category: HG]]
[[Category: beta sandwich]]
[[Category: immunoglobulin-like]]
[[Category: receptor]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:55:30 2007''

Latest revision as of 06:38, 30 October 2024

CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF A HUMAN FCGRIII

1fnl, resolution 1.80Å

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