CAD protein: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Michal Harel (talk | contribs) No edit summary |
No edit summary |
||
| (4 intermediate revisions by 2 users not shown) | |||
| Line 1: | Line 1: | ||
<StructureSection load='6hg3' size='340' side='right' caption='CAD protein dihydroorotatase subunit | <StructureSection load='6hg3' size='340' side='right' caption='Human CAD protein dihydroorotatase subunit containing modified Lys complex with dihydroorotate, formate and Zn+2 ions (PDB ID [[6hg3]])' scene='91/917453/Cv/1'> | ||
== Function == | == Function == | ||
'''CAD protein''' is a trifunctional enzyme which contains dihydroorotase domain (DHO), aspartate transcarbamoylase domain (ATC) and carbamoylphosphate synthetase domain<ref>PMID:28552578</ref>. | '''CAD protein''' is a trifunctional enzyme which contains dihydroorotase domain (DHO), aspartate transcarbamoylase domain (ATC) and carbamoylphosphate synthetase domain<ref>PMID:28552578</ref>. The CAD protein catalyzes the first 3 of 6 reactions required for pyrimidine biosynthesis. | ||
== Disease == | == Disease == | ||
| Line 12: | Line 12: | ||
== Structural highlights == | == Structural highlights == | ||
The 3D structure of CAD protein dihydroorotase subunit complex with dihydroorotate shows the <scene name='91/917453/Cv/4'>active site</scene> containing <scene name='91/917453/Cv/5'>2 Zn+2 ions</scene> and a flexible loop containing conserved Thr and Phe in a loop-out conformation<ref>PMID:30315107</ref>. Water molecules are shown as red spheres. | |||
==3D structures of CAD protein== | ==3D structures of CAD protein== | ||
Latest revision as of 14:58, 14 July 2022
| ||||||||||||
