Phytase: Difference between revisions
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<StructureSection load='3mmj' size='340' side='right' caption='Phytase in complex with inositol hexakisphosphate, phosphate, | <StructureSection load='3mmj' size='340' side='right' caption='Phytase in complex with inositol hexakisphosphate, phosphate, acetate, glycerol and Cl- ion (PDB code [[3mmj]])' scene='91/917455/Cv/1'> | ||
== Function == | == Function == | ||
'''Phytase''' (PHYT) catalyzes the hydrolysis of phytate (myo-inositol hexakisphosphate) to myo-inositol and inorganic phosphate <ref>PMID:9025298</ref>. PHYT are a subclass of the histidine acid phosphatase<ref>PMID:9025298</ref>. Phytate is the main phosphorus storage system in plant seeds. | '''Phytase''' or '''purple acid phosphatase''' or '''acidphosphatase''' (PHYT) catalyzes the hydrolysis of phytate (myo-inositol hexakisphosphate) to myo-inositol and inorganic phosphate <ref>PMID:9025298</ref>. PHYT are a subclass of the histidine acid phosphatase<ref>PMID:9025298</ref>. Phytate is the main phosphorus storage system in plant seeds. Phytate is indigestible by monogastric animals and humans<ref>PMID:32271147</ref>. | ||
== Relevance == | == Relevance == | ||
PHYT is found in plant material and is used to increase the nutritional quality of grains, legumes, seeds and corn. | PHYT is found in plant material and is used to increase the nutritional quality of grains, legumes, seeds and corn. PHYT is used as a dietary supplement in broiler nutrition<ref>PMID:31610823</ref>. Studies show that supplementing PHYT can reduce the need for calcium phosphate and increase digestive health. | ||
== Structural highlights == | == Structural highlights == | ||
The 3D structure of the complex between phytase and myo-inositol hexakisphosphate shows the extensive contacts of the phosphoryl groups of the substrate binding in the highly basic binding pocket<ref>PMID:22139834</ref>. | The 3D structure of <scene name='91/917455/Cv/6'>the complex between phytase and myo-inositol hexakisphosphate</scene> shows the extensive contacts of the phosphoryl groups of the substrate binding in the <scene name='91/917455/Cv/8'>highly basic binding pocket</scene><ref>PMID:22139834</ref>. Positively charged residues are colored in magenta; water molecules are shown as red spheres. | ||
==3D structures of phytase== | ==3D structures of phytase== | ||
Latest revision as of 10:35, 30 August 2023
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