7try: Difference between revisions

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'''Unreleased structure'''


The entry 7try is ON HOLD
==Cryo-EM structure of corticotropin releasing factor receptor 2 bound to Urocortin 1 and coupled with heterotrimeric G11 protein==
<StructureSection load='7try' size='340' side='right'caption='[[7try]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7try]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TRY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TRY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7try FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7try OCA], [https://pdbe.org/7try PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7try RCSB], [https://www.ebi.ac.uk/pdbsum/7try PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7try ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CRFR2_HUMAN CRFR2_HUMAN] G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The ability to couple with multiple G protein subtypes, such as G(s), G(i/o), or G(q/11), by a given G protein-coupled receptor (GPCR) is critical for many physiological processes. Over the past few years, the cryo-EM structures for all 15 members of the medically important class B GPCRs, all in complex with G(s) protein, have been determined. However, no structure of class B GPCRs with G(q/11) has been solved to date, limiting our understanding of the precise mechanisms of G protein coupling selectivity. Here we report the structures of corticotropin releasing factor receptor 2 (CRF2R) bound to Urocortin 1 (UCN1), coupled with different classes of heterotrimeric G proteins, G(11) and G(o). We compare these structures with the structure of CRF2R in complex with G(s) to uncover the structural differences that determine the selective coupling of G protein subtypes by CRF2R. These results provide important insights into the structural basis for the ability of CRF2R to couple with multiple G protein subtypes.


Authors: Zhao, L.-H., Lin, J., Mao, C., Zhou, X.E., Ji, S., Shen, D., Xiao, P., Melcher, K., Zhang, Y., Yu, X., Xu, H.E.
,  PMID:36335102<ref>PMID:36335102</ref>


Description: Cryo-EM structure of corticotropin releasing factor receptor 2 bound to Urocortin 1 and coupled with heterotrimeric G11 protein
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Zhang, Y]]
<div class="pdbe-citations 7try" style="background-color:#fffaf0;"></div>
[[Category: Zhou, X.E]]
 
[[Category: Xu, H.E]]
==See Also==
[[Category: Yu, X]]
*[[Transducin 3D structures|Transducin 3D structures]]
[[Category: Zhao, L.-H]]
== References ==
[[Category: Lin, J]]
<references/>
[[Category: Melcher, K]]
__TOC__
[[Category: Xiao, P]]
</StructureSection>
[[Category: Shen, D]]
[[Category: Homo sapiens]]
[[Category: Ji, S]]
[[Category: Large Structures]]
[[Category: Mao, C]]
[[Category: Rattus norvegicus]]
[[Category: Synthetic construct]]
[[Category: Ji S]]
[[Category: Lin J]]
[[Category: Mao C]]
[[Category: Melcher K]]
[[Category: Shen D]]
[[Category: Xiao P]]
[[Category: Xu HE]]
[[Category: Yu X]]
[[Category: Zhang Y]]
[[Category: Zhao L-H]]
[[Category: Zhou XE]]
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