8dq7: Difference between revisions

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New page: '''Unreleased structure''' The entry 8dq7 is ON HOLD until Paper Publication Authors: Wu, K., Dulchavsky, M., Li, J., Bardwell, J.C.A. Description: The structure of NicA2 variant F104L...
 
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'''Unreleased structure'''


The entry 8dq7 is ON HOLD  until Paper Publication
==The structure of NicA2 variant F104L/A107T/S146I/G317D/H368R/L449V/N462S from Pseudomonas putida==
 
<StructureSection load='8dq7' size='340' side='right'caption='[[8dq7]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
Authors: Wu, K., Dulchavsky, M., Li, J., Bardwell, J.C.A.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8dq7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_putida_S16 Pseudomonas putida S16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DQ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DQ7 FirstGlance]. <br>
Description: The structure of NicA2 variant F104L/A107T/S146I/G317D/H368R/L449V/N462S from Pseudomonas putida
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FDA:DIHYDROFLAVINE-ADENINE+DINUCLEOTIDE'>FDA</scene></td></tr>
[[Category: Li, J]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dq7 OCA], [https://pdbe.org/8dq7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dq7 RCSB], [https://www.ebi.ac.uk/pdbsum/8dq7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dq7 ProSAT]</span></td></tr>
[[Category: Dulchavsky, M]]
</table>
[[Category: Wu, K]]
== Function ==
[[Category: Bardwell, J.C.A]]
[https://www.uniprot.org/uniprot/NICA2_PSEP6 NICA2_PSEP6] Involved in nicotine degradation (PubMed:24204321, PubMed:26237398, PubMed:29812904, PubMed:33432238). Catalyzes the conversion of nicotine to N-methylmyosmine (PubMed:24204321, PubMed:29812904, PubMed:33432238, PubMed:33464876). N-methylmyosmine undergoes spontaneous hydrolysis to form pseudooxynicotine (PN) (PubMed:24204321). S-nicotine is the optimal substrate (PubMed:29812904). Has lower activity with some nicotine analogs, but shows no activity towards neurotransmitters, including serotonin, dopamine, and norepinephrine, nicotine metabolites and common neuroactive drugs (PubMed:29812904). The enzyme is stereospecific with poor activity with (R)-nicotine as the substrate (PubMed:29812904). The c-type cytochrome protein CycN is the physiological electron acceptor (PubMed:33432238). O(2) is a poor electron acceptor (PubMed:33432238, PubMed:33464876).<ref>PMID:24204321</ref> <ref>PMID:26237398</ref> <ref>PMID:29812904</ref> <ref>PMID:33432238</ref> <ref>PMID:33464876</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pseudomonas putida S16]]
[[Category: Bardwell JCA]]
[[Category: Dulchavsky M]]
[[Category: Li J]]
[[Category: Wu K]]
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