8dr4: Difference between revisions
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New page: '''Unreleased structure''' The entry 8dr4 is ON HOLD Authors: Schrecker, M., Hite, R.K. Description: Open state of RFC:PCNA bound to a 3'' ss/dsDNA junction (DNA2) without NTD [[Catego... |
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==Open state of RFC:PCNA bound to a 3' ss/dsDNA junction (DNA2) without NTD== | |||
<StructureSection load='8dr4' size='340' side='right'caption='[[8dr4]], [[Resolution|resolution]] 2.45Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8dr4]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DR4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DR4 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.45Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dr4 OCA], [https://pdbe.org/8dr4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dr4 RCSB], [https://www.ebi.ac.uk/pdbsum/8dr4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dr4 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/RFC1_YEAST RFC1_YEAST] Component of the ATP-dependent clamp loader RFC complex for the POL30/PCNA homotrimer DNA clamp. During a clamp loading circle, the RFC:clamp complex binds to DNA and the recognition of the double-stranded/single-stranded junction stimulates ATP hydrolysis by RFC. The complex presumably provides bipartite ATP sites in which one subunit supplies a catalytic site for hydrolysis of ATP bound to the neighboring subunit. Dissociation of RFC from the clamp leaves the clamp encircling DNA. Replication factor C (RFC or activator 1) complex acts during elongation of primed DNA templates by DNA polymerase delta and epsilon. RFC has an essential but redundant activity in sister chromatid cohesion establishment. | |||
==See Also== | |||
*[[Proliferating cell nuclear antigen 3D structures|Proliferating cell nuclear antigen 3D structures]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: Hite | [[Category: Large Structures]] | ||
[[Category: Schrecker | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: Hite RK]] | |||
[[Category: Schrecker M]] | |||
Latest revision as of 09:41, 14 February 2024
Open state of RFC:PCNA bound to a 3' ss/dsDNA junction (DNA2) without NTD
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