7ufb: Difference between revisions
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==CYP3A4 bound to an inhibitor== | ==CYP3A4 bound to an inhibitor== | ||
<StructureSection load='7ufb' size='340' side='right'caption='[[7ufb]]' scene=''> | <StructureSection load='7ufb' size='340' side='right'caption='[[7ufb]], [[Resolution|resolution]] 2.25Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UFB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UFB FirstGlance]. <br> | <table><tr><td colspan='2'>[[7ufb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UFB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UFB FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ufb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ufb OCA], [https://pdbe.org/7ufb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ufb RCSB], [https://www.ebi.ac.uk/pdbsum/7ufb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ufb ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NJ0:(2~{R})-3-phenyl-2-[(2~{S})-3-phenyl-2-(2-pyridin-3-ylethanoylamino)propyl]sulfanyl-~{N}-(pyridin-3-ylmethyl)propanamide'>NJ0</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ufb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ufb OCA], [https://pdbe.org/7ufb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ufb RCSB], [https://www.ebi.ac.uk/pdbsum/7ufb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ufb ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/CP3A4_HUMAN CP3A4_HUMAN] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.<ref>PMID:11159812</ref> | |||
==See Also== | |||
*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Sevrioukova I]] | [[Category: Sevrioukova I]] | ||
