7uff: Difference between revisions
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==Human CYP3A4 bound to an inhibitor== | ==Human CYP3A4 bound to an inhibitor== | ||
<StructureSection load='7uff' size='340' side='right'caption='[[7uff]]' scene=''> | <StructureSection load='7uff' size='340' side='right'caption='[[7uff]], [[Resolution|resolution]] 2.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UFF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UFF FirstGlance]. <br> | <table><tr><td colspan='2'>[[7uff]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UFF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UFF FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uff OCA], [https://pdbe.org/7uff PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uff RCSB], [https://www.ebi.ac.uk/pdbsum/7uff PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uff ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NYF:~{N}-[2-oxidanylidene-2-[[(2~{S})-1-[(2~{R})-1-oxidanylidene-3-phenyl-1-(3-pyridin-3-ylpropylamino)propan-2-yl]sulfanyl-3-phenyl-propan-2-yl]amino]ethyl]pyridine-3-carboxamide'>NYF</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uff OCA], [https://pdbe.org/7uff PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uff RCSB], [https://www.ebi.ac.uk/pdbsum/7uff PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uff ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/CP3A4_HUMAN CP3A4_HUMAN] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.<ref>PMID:11159812</ref> | |||
==See Also== | |||
*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Sevrioukova IF]] | [[Category: Sevrioukova IF]] | ||
Latest revision as of 14:44, 13 August 2026
Human CYP3A4 bound to an inhibitor
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