1hst: Difference between revisions

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[[Image:1hst.gif|left|200px]]


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==CRYSTAL STRUCTURE OF GLOBULAR DOMAIN OF HISTONE H5 AND ITS IMPLICATIONS FOR NUCLEOSOME BINDING==
The line below this paragraph, containing "STRUCTURE_1hst", creates the "Structure Box" on the page.
<StructureSection load='1hst' size='340' side='right'caption='[[1hst]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1hst]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HST OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HST FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hst FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hst OCA], [https://pdbe.org/1hst PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hst RCSB], [https://www.ebi.ac.uk/pdbsum/1hst PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hst ProSAT]</span></td></tr>
{{STRUCTURE_1hst| PDB=1hst |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/H5_CHICK H5_CHICK] Histone H5 performs the same function as H1, being necessary for the condensation of nucleosome chains into higher order structures, and replaces histone H1 in certain cells.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hs/1hst_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hst ConSurf].
<div style="clear:both"></div>


'''CRYSTAL STRUCTURE OF GLOBULAR DOMAIN OF HISTONE H5 AND ITS IMPLICATIONS FOR NUCLEOSOME BINDING'''
==See Also==
 
*[[Histone 3D structures|Histone 3D structures]]
 
__TOC__
==Overview==
</StructureSection>
The structure of GH5, the globular domain of the linker histone H5, has been solved to 2.5 A resolution by multiwavelength anomalous diffraction on crystals of the selenomethionyl protein. The structure shows a striking similarity to the DNA-binding domain of the catabolite gene activator protein CAP, thereby providing a possible model for the binding of GH5 to DNA.
 
==About this Structure==
1HST is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HST OCA].
 
==Reference==
Crystal structure of globular domain of histone H5 and its implications for nucleosome binding., Ramakrishnan V, Finch JT, Graziano V, Lee PL, Sweet RM, Nature. 1993 Mar 18;362(6417):219-23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8384699 8384699]
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Finch, J T.]]
[[Category: Finch JT]]
[[Category: Graziano, V.]]
[[Category: Graziano V]]
[[Category: Lee, P L.]]
[[Category: Lee PL]]
[[Category: Ramakrishnan, V.]]
[[Category: Ramakrishnan V]]
[[Category: Sweet, R M.]]
[[Category: Sweet RM]]
[[Category: Chromosomal protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 19:11:48 2008''
Retrieved from "https://proteopedia.org/1hst"