7yll: Difference between revisions
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New page: '''Unreleased structure''' The entry 7yll is ON HOLD Authors: Xiao-Xue, Y., Li-Fei, T., Hong-Wei, G. Description: Crystal structure of TTEDbh Category: Unreleased Structures [[Cate... |
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==Crystal structure of TTEDbh== | |||
<StructureSection load='7yll' size='340' side='right'caption='[[7yll]], [[Resolution|resolution]] 2.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7yll]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caldanaerobacter_subterraneus_subsp._tengcongensis_MB4 Caldanaerobacter subterraneus subsp. tengcongensis MB4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YLL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YLL FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6000092Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yll OCA], [https://pdbe.org/7yll PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yll RCSB], [https://www.ebi.ac.uk/pdbsum/7yll PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yll ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[https://www.uniprot.org/uniprot/DPO4_CALS4 DPO4_CALS4] Poorly processive, error-prone DNA polymerase involved in translesion repair and untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity (By similarity). Involved in translesional synthesis. Primer extension fidelity in vitro is temperature-dependent. Inserts a correct base opposite templating bases at 70 degrees Celsius, but at 37 degrees Celsius in addition to correct base pairing, base transitions, transversions and frameshifts can occur. Preferably forms erroneous base pairs C:T. Bypasses 8-oxo-dG oxidative damage by incorporating dATP or dCTP opposite of the damaged DNA template site at both temperatures in vitro (PubMed:37683741).[UniProtKB:Q47155][HAMAP-Rule:MF_01113]<ref>PMID:37683741</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Caldanaerobacter subterraneus subsp. tengcongensis MB4]] | |||
[[Category: Large Structures]] | |||
[[Category: Gao H]] | |||
[[Category: Tian L]] | |||
[[Category: Yan X]] | |||
