8dsm: Difference between revisions
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New page: '''Unreleased structure''' The entry 8dsm is ON HOLD Authors: Ratia, K., Xiong, R., Shen, Z., Thatcher, G.R. Description: Human NAMPT in complex with inhibitor ZN-4-3 [[Category: Unrel... |
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==Human NAMPT in complex with inhibitor ZN-4-3== | |||
<StructureSection load='8dsm' size='340' side='right'caption='[[8dsm]], [[Resolution|resolution]] 2.75Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8dsm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DSM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DSM FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=TK0:(3~{S})-~{N}-(1-benzothiophen-5-ylmethyl)-1-[6-[4-[2-[[(~{E})-3-pyridin-3-ylprop-2-enoyl]amino]ethyl]phenyl]thieno[2,3-d]pyrimidin-4-yl]piperidine-3-carboxamide'>TK0</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dsm OCA], [https://pdbe.org/8dsm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dsm RCSB], [https://www.ebi.ac.uk/pdbsum/8dsm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dsm ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity). | |||
==See Also== | |||
*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Ratia K]] | ||
[[Category: | [[Category: Shen Z]] | ||
[[Category: Thatcher GR]] | |||
[[Category: Xiong R]] | |||
