7p85: Difference between revisions
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==Engineered phosphotriesterase BdPTE 10-2-C3(C59V/C227V) in complex with ethyl-4-methylbenzylphosphonate== | ==Engineered phosphotriesterase BdPTE 10-2-C3(C59V/C227V) in complex with ethyl-4-methylbenzylphosphonate== | ||
<StructureSection load='7p85' size='340' side='right'caption='[[7p85]]' scene=''> | <StructureSection load='7p85' size='340' side='right'caption='[[7p85]], [[Resolution|resolution]] 1.47Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7P85 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7P85 FirstGlance]. <br> | <table><tr><td colspan='2'>[[7p85]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Brevundimonas_diminuta Brevundimonas diminuta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7P85 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7P85 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7p85 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7p85 OCA], [https://pdbe.org/7p85 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7p85 RCSB], [https://www.ebi.ac.uk/pdbsum/7p85 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7p85 ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.47Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5ZG:ethyl-4-methylbenzylphosphonate'>5ZG</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7p85 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7p85 OCA], [https://pdbe.org/7p85 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7p85 RCSB], [https://www.ebi.ac.uk/pdbsum/7p85 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7p85 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/OPD_BREDI OPD_BREDI] Has an unusual substrate specificity for synthetic organophosphate triesters and phosphorofluoridates. All of the phosphate triesters found to be substrates are synthetic compounds. The identity of any naturally occurring substrate for the enzyme is unknown. Has no detectable activity with phosphate monoesters or diesters and no activity as an esterase or protease. It catalyzes the hydrolysis of the insecticide paraoxon at a rate approaching the diffusion limit and thus appears to be optimally evolved for utilizing this synthetic substrate. | |||
==See Also== | |||
*[[Phosphotriesterase 3D structures|Phosphotriesterase 3D structures]] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Brevundimonas diminuta]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Eichinger A]] | [[Category: Eichinger A]] | ||
[[Category: Skerra A]] | [[Category: Skerra A]] | ||
Latest revision as of 07:54, 7 February 2024
Engineered phosphotriesterase BdPTE 10-2-C3(C59V/C227V) in complex with ethyl-4-methylbenzylphosphonate
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