7yq8: Difference between revisions
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New page: '''Unreleased structure''' The entry 7yq8 is ON HOLD Authors: Description: Category: Unreleased Structures |
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==Cryo-EM structure of human topoisomerase II beta in complex with DNA and etoposide== | |||
<StructureSection load='7yq8' size='340' side='right'caption='[[7yq8]], [[Resolution|resolution]] 3.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7yq8]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YQ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YQ8 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.9Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EVP:(5S,5AR,8AR,9R)-9-(4-HYDROXY-3,5-DIMETHOXYPHENYL)-8-OXO-5,5A,6,8,8A,9-HEXAHYDROFURO[3,4 6,7]NAPHTHO[2,3-D][1,3]DIOXOL-5-YL+4,6-O-[(1R)-ETHYLIDENE]-BETA-D-GLUCOPYRANOSIDE'>EVP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yq8 OCA], [https://pdbe.org/7yq8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yq8 RCSB], [https://www.ebi.ac.uk/pdbsum/7yq8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yq8 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TOP2B_HUMAN TOP2B_HUMAN] Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.<ref>PMID:10684600</ref> <ref>PMID:12837248</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Bu H]] | |||
[[Category: Bunch H]] | |||
[[Category: Cong A]] | |||
[[Category: Ehara H]] | |||
[[Category: Jang J]] | |||
[[Category: Jeong J]] | |||
[[Category: Kim D]] | |||
[[Category: Naganuma M]] | |||
[[Category: Nakagawa R]] | |||
[[Category: Schellenberg MJ]] | |||
[[Category: Sekine S]] | |||
