7vmn: Difference between revisions
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==== | ==Structure of recombinant RyR2 (EGTA dataset, class 2, closed state)== | ||
<StructureSection load='7vmn' size='340' side='right'caption='[[7vmn]]' scene=''> | <StructureSection load='7vmn' size='340' side='right'caption='[[7vmn]], [[Resolution|resolution]] 3.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[7vmn]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VMN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VMN FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vmn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vmn OCA], [https://pdbe.org/7vmn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vmn RCSB], [https://www.ebi.ac.uk/pdbsum/7vmn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vmn ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vmn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vmn OCA], [https://pdbe.org/7vmn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vmn RCSB], [https://www.ebi.ac.uk/pdbsum/7vmn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vmn ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/RYR2_MOUSE RYR2_MOUSE] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.<ref>PMID:10473538</ref> <ref>PMID:9628868</ref> <ref>PMID:21098440</ref> <ref>PMID:20431056</ref> | |||
==See Also== | |||
*[[FKBP 3D structures|FKBP 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mus musculus]] | ||
[[Category: Kikkawa M]] | |||
[[Category: Kobayashi T]] | |||
[[Category: Kodama M]] | |||
[[Category: Kurebayashi N]] | |||
[[Category: Murayama T]] | |||
[[Category: Ogawa H]] | |||
[[Category: Tsutsumi A]] | |||
Latest revision as of 06:21, 19 June 2024
Structure of recombinant RyR2 (EGTA dataset, class 2, closed state)
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