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<StructureSection load='2xbu' size='340' side='right'caption='[[2xbu]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='2xbu' size='340' side='right'caption='[[2xbu]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2xbu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XBU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XBU FirstGlance]. <br>
<table><tr><td colspan='2'>[[2xbu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XBU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XBU FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2jky|2jky]], [[2jkz|2jkz]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Hypoxanthine_phosphoribosyltransferase Hypoxanthine phosphoribosyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.8 2.4.2.8] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xbu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xbu OCA], [https://pdbe.org/2xbu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xbu RCSB], [https://www.ebi.ac.uk/pdbsum/2xbu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xbu ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xbu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xbu OCA], [https://pdbe.org/2xbu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xbu RCSB], [https://www.ebi.ac.uk/pdbsum/2xbu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xbu ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/HPRT_YEAST HPRT_YEAST]] Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.<ref>PMID:371963</ref> <ref>PMID:6170313</ref> <ref>PMID:7035445</ref> <ref>PMID:6392474</ref> <ref>PMID:9335580</ref> <ref>PMID:11035032</ref> <ref>PMID:18245832</ref>
[https://www.uniprot.org/uniprot/HPRT_YEAST HPRT_YEAST] Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.<ref>PMID:371963</ref> <ref>PMID:6170313</ref> <ref>PMID:7035445</ref> <ref>PMID:6392474</ref> <ref>PMID:9335580</ref> <ref>PMID:11035032</ref> <ref>PMID:18245832</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Atcc 18824]]
[[Category: Hypoxanthine phosphoribosyltransferase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Boissier, F]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Breton, A]]
[[Category: Boissier F]]
[[Category: Daignan-Fornier, B]]
[[Category: Breton A]]
[[Category: Dautant, A]]
[[Category: Daignan-Fornier B]]
[[Category: Giraud, M F]]
[[Category: Dautant A]]
[[Category: Moynie, L]]
[[Category: Giraud MF]]
[[Category: Flip peptide-plane]]
[[Category: Moynie L]]
[[Category: Glycosyltransferase]]
[[Category: Purine salvage]]
[[Category: Transferase]]
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