3ws8: Difference between revisions
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<StructureSection load='3ws8' size='340' side='right'caption='[[3ws8]], [[Resolution|resolution]] 2.60Å' scene=''> | <StructureSection load='3ws8' size='340' side='right'caption='[[3ws8]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3ws8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3ws8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WS8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WS8 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=X4C:8-METHYL-6-[2-(5-METHYL-1-PHENYL-1H-BENZIMIDAZOL-2-YL)ETHYL]IMIDAZO[1,5-A]PYRIMIDINE'>X4C</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=X4C:8-METHYL-6-[2-(5-METHYL-1-PHENYL-1H-BENZIMIDAZOL-2-YL)ETHYL]IMIDAZO[1,5-A]PYRIMIDINE'>X4C</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ws8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ws8 OCA], [https://pdbe.org/3ws8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ws8 RCSB], [https://www.ebi.ac.uk/pdbsum/3ws8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ws8 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ws8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ws8 OCA], [https://pdbe.org/3ws8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ws8 RCSB], [https://www.ebi.ac.uk/pdbsum/3ws8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ws8 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Amano | [[Category: Amano Y]] | ||
[[Category: Honbou | [[Category: Honbou K]] | ||
Latest revision as of 13:25, 8 November 2023
Crystal structure of PDE10A in complex with a benzimidazole inhibitor
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