7yr9: Difference between revisions
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New page: '''Unreleased structure''' The entry 7yr9 is ON HOLD Authors: Tsutsumi, E., Niwa, S., Takeda, K. Description: Crystal structure of the immature form of TtPetA [[Category: Unreleased St... |
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The | ==Crystal structure of the immature form of TtPetA== | ||
<StructureSection load='7yr9' size='340' side='right'caption='[[7yr9]], [[Resolution|resolution]] 1.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7yr9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermochromatium_tepidum Thermochromatium tepidum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YR9 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yr9 OCA], [https://pdbe.org/7yr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yr9 RCSB], [https://www.ebi.ac.uk/pdbsum/7yr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yr9 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/D1MZ11_THETI D1MZ11_THETI] Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.[ARBA:ARBA00002444] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Iron-sulfur clusters are prosthetic groups of proteins involved in various biological processes. However, details of the immature state of the iron-sulfur cluster into proteins have not yet been elucidated. We report here the first structural analysis of the Zn-containing form of a Rieske-type iron-sulfur protein, PetA, from Thermochromatium tepidum (TtPetA) by X-ray crystallography and small-angle X-ray scattering analysis. The Zn-containing form of TtPetA was indicated to be a dimer in solution. The zinc ion adopts a regular tetra-coordination with two chloride ions and two cysteine residues. Only a histidine residue in the cluster-binding site exhibited a conformational difference from the [2Fe-2S] containing form. The Zn-containing structure indicates that the conformation of the cluster binding site is already constructed and stabilized before insertion of [2Fe-2S]. The binding mode of ZnCl(2), similar to the [2Fe-2S] cluster, suggests that the zinc ions might be involved in the insertion of the [2Fe-2S] cluster. | |||
Structure of a putative immature form of a Rieske-type iron-sulfur protein in complex with zinc chloride.,Tsutsumi E, Niwa S, Takeda R, Sakamoto N, Okatsu K, Fukai S, Ago H, Nagao S, Sekiguchi H, Takeda K Commun Chem. 2023 Sep 9;6(1):190. doi: 10.1038/s42004-023-01000-6. PMID:37689761<ref>PMID:37689761</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 7yr9" style="background-color:#fffaf0;"></div> | ||
[[Category: Niwa | == References == | ||
[[Category: Tsutsumi | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Thermochromatium tepidum]] | |||
[[Category: Niwa S]] | |||
[[Category: Takeda K]] | |||
[[Category: Tsutsumi E]] | |||
Latest revision as of 14:34, 20 September 2023
Crystal structure of the immature form of TtPetA
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