8dz7: Difference between revisions

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New page: '''Unreleased structure''' The entry 8dz7 is ON HOLD Authors: Meisburger, S.P., Imran, S.M.S., Ando, N. Description: Hen lysozyme in orthorhombic space group at ambient temperature -di...
 
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'''Unreleased structure'''


The entry 8dz7 is ON HOLD
==Hen lysozyme in orthorhombic space group at ambient temperature - diffuse scattering dataset==
<StructureSection load='8dz7' size='340' side='right'caption='[[8dz7]], [[Resolution|resolution]] 1.34&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8dz7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DZ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DZ7 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.34&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dz7 OCA], [https://pdbe.org/8dz7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dz7 RCSB], [https://www.ebi.ac.uk/pdbsum/8dz7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dz7 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The breathing motions of proteins are thought to play a critical role in function. However, current techniques to study key collective motions are limited to spectroscopy and computation. We present a high-resolution experimental approach based on the total scattering from protein crystals at room temperature (TS/RT-MX) that captures both structure and collective motions. To reveal the scattering signal from protein motions, we present a general workflow that enables robust subtraction of lattice disorder. The workflow introduces two methods: GOODVIBES, a detailed and refinable lattice disorder model based on the rigid-body vibrations of a crystalline elastic network; and DISCOBALL, an independent method of validation that estimates the displacement covariance between proteins in the lattice in real space. Here, we demonstrate the robustness of this workflow and further demonstrate how it can be interfaced with MD simulations towards obtaining high-resolution insight into functionally important protein motions.


Authors: Meisburger, S.P., Imran, S.M.S., Ando, N.
Robust total X-ray scattering workflow to study correlated motion of proteins in crystals.,Meisburger SP, Case DA, Ando N Nat Commun. 2023 Mar 3;14(1):1228. doi: 10.1038/s41467-023-36734-3. PMID:36869043<ref>PMID:36869043</ref>


Description: Hen lysozyme in orthorhombic space group at ambient temperature -diffuse scattering dataset
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Imran, S.M.S]]
<div class="pdbe-citations 8dz7" style="background-color:#fffaf0;"></div>
[[Category: Meisburger, S.P]]
 
[[Category: Ando, N]]
==See Also==
*[[Lysozyme 3D structures|Lysozyme 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Gallus gallus]]
[[Category: Large Structures]]
[[Category: Ando N]]
[[Category: Imran SMS]]
[[Category: Meisburger SP]]
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