3zvk: Difference between revisions

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<StructureSection load='3zvk' size='340' side='right'caption='[[3zvk]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='3zvk' size='340' side='right'caption='[[3zvk]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3zvk]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/"rickettsia_felis"_higgins_et_al._1996 "rickettsia felis" higgins et al. 1996]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZVK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZVK FirstGlance]. <br>
<table><tr><td colspan='2'>[[3zvk]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Rickettsia_felis Rickettsia felis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZVK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZVK FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zvk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zvk OCA], [https://pdbe.org/3zvk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zvk RCSB], [https://www.ebi.ac.uk/pdbsum/3zvk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zvk ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zvk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zvk OCA], [https://pdbe.org/3zvk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zvk RCSB], [https://www.ebi.ac.uk/pdbsum/3zvk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zvk ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/Q4UNB2_RICFE Q4UNB2_RICFE]] Toxic component of a toxin-antitoxin (TA) module. An RNase (By similarity).[HAMAP-Rule:MF_00265]  
[https://www.uniprot.org/uniprot/VAPC2_RICFE VAPC2_RICFE] Toxic component of a type II toxin-antitoxin (TA) system. Has ssRNase activity. Upon expression in E.coli or S.cerevisiae inhibits growth in liquid culture; in S.cerevisiae its expression leads to apoptosis-like characteristics. Rapidly induces apoptosis (within 2 hours) upon microinjection into mouse fibroblasts (L929 line); pretreatment of cells with dexamethasone protects them. Probably contributes to host cell death if bacterial cell lysis occurs during host infection. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB2, its RNase activity is partially inhibited in vitro by VapB2 (PubMed:22046301).[HAMAP-Rule:MF_00265]<ref>PMID:22046301</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Rickettsia felis higgins et al. 1996]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Cambillau, C]]
[[Category: Rickettsia felis]]
[[Category: Mate, M J]]
[[Category: Cambillau C]]
[[Category: Ortiz-Lombardia, M]]
[[Category: Mate MJ]]
[[Category: Antitoxin-toxin-dna complex]]
[[Category: Ortiz-Lombardia M]]
[[Category: Protein-dna complex]]
Retrieved from "https://proteopedia.org/3zvk"