Aconitase: Difference between revisions
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==Function== | ==Function== | ||
[[Aconitase]] (ACO, EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.3 4.2.1.3]) | [[Aconitase]] (ACO, EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.3 4.2.1.3]) is an enzymatic domain that confers the ability to catalyse the equilibrium | ||
:citrate = aconitate + H<sub>2</sub>O = L-isocitrate | :citrate = aconitate + H<sub>2</sub>O = L-isocitrate | ||
This reaction is part of the citrate (TCA-, Krebs-)cycle. | This reaction is part of the citrate (TCA-, Krebs-)cycle. | ||
In most organisms, there is a cytosolic enzyme with an ACO domain (cAc), and in eukaryotes, a second copy of it was introduced with mitochondria (mAc). Plants developed even more copies in mitochondria. | In most organisms, there is a cytosolic enzyme with an ACO domain (cAc), and in eukaryotes, a second copy of it was introduced with mitochondria (mAc). Plants developed even more copies in mitochondria. | ||
Aconitase contains a Fe4S4 cluster which converts to Fe3S4 when the enzyme is inactive. In humans, two types of ACO are expressed: the soluble '''ACO1''' and the mitochondrial '''ACO2'''. | Aconitase contains a Fe4S4 cluster which converts to Fe3S4 when the enzyme is inactive. In humans, two types of ACO are expressed: the soluble '''ACO1''' and the mitochondrial '''ACO2'''. Two types of '''ACO X''' were characterized as '''mevalonate 5-phosphate dehydratase''' and '''cis-3-hydroxy-L-proline dehydrates'''. | ||
Aconitase from pig (PDB [[7acn]]) is a single polypeptide (M<sub>r</sub> 83kD) that catalyzes the reversible isomerization of citrate and isocitrate.<ref name="Zheng">PMID 1313811</ref> It is the second enzyme in the Citric acid cycle, which is a series of enzyme-catalysed chemical reactions that is crucial to aerobic cellular respiration and the production of ATP. See also:<br /> | Aconitase from pig (PDB [[7acn]]) is a single polypeptide (M<sub>r</sub> 83kD) that catalyzes the reversible isomerization of citrate and isocitrate.<ref name="Zheng">PMID 1313811</ref> It is the second enzyme in the Citric acid cycle, which is a series of enzyme-catalysed chemical reactions that is crucial to aerobic cellular respiration and the production of ATP. See also:<br /> | ||
*[[Citric Acid Cycle]] | *[[Citric Acid Cycle]] | ||
*[[Krebs cycle step 2]] | *[[Krebs cycle step 2]] | ||
*[[Glyoxylate cycle]] | |||
==Structure== | ==Structure== | ||
