2mny: Difference between revisions
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==NMR Structure of KDM5B PHD1 finger== | ==NMR Structure of KDM5B PHD1 finger== | ||
<StructureSection load='2mny' size='340' side='right'caption='[[2mny | <StructureSection load='2mny' size='340' side='right'caption='[[2mny]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2mny]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MNY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MNY FirstGlance]. <br> | <table><tr><td colspan='2'>[[2mny]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MNY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MNY FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mny OCA], [https://pdbe.org/2mny PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mny RCSB], [https://www.ebi.ac.uk/pdbsum/2mny PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mny ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mny OCA], [https://pdbe.org/2mny PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mny RCSB], [https://www.ebi.ac.uk/pdbsum/2mny PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mny ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Cao | [[Category: Cao C]] | ||
[[Category: Guo | [[Category: Guo X]] | ||
[[Category: Lan | [[Category: Lan WX]] | ||
[[Category: Rong | [[Category: Rong NY]] | ||
[[Category: Song | [[Category: Song YJ]] | ||
[[Category: Xu | [[Category: Xu YH]] | ||
[[Category: Xu | [[Category: Xu YW]] | ||
[[Category: Yang | [[Category: Yang HR]] | ||
[[Category: Zhang | [[Category: Zhang Y]] | ||
Latest revision as of 06:08, 15 May 2024
NMR Structure of KDM5B PHD1 finger
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