4ani: Difference between revisions

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== Structural highlights ==

<table><tr><td colspan='2'>[[4ani]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Geoka Geoka~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ANI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ANI FirstGlance]. <br>

<table><tr><td colspan='2'>[[4ani]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_kaustophilus_HTA426 Geobacillus kaustophilus HTA426]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ANI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ANI FirstGlance]. <br>

</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>~~[[~~2v7y~~|~~2v7y~~]]~~</div>~~</td></tr>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.094Å</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ani FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ani OCA], [https://pdbe.org/4ani PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ani RCSB], [https://www.ebi.ac.uk/pdbsum/4ani PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ani ProSAT]</span></td></tr>

</table>

== Function ==

[[https://www.uniprot.org/uniprot/GRPE_GEOKA GRPE_GEOKA]] Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding ~~(By similarity). [[https://www.uniprot.org/uniprot/DNAK_GEOKA DNAK_GEOKA]] Acts as a chaperone~~ (By similarity).

[https://www.uniprot.org/uniprot/GRPE_GEOKA GRPE_GEOKA] Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding (By similarity).

== Publication Abstract from PubMed ==

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__TOC__

</StructureSection>

[[Category: ~~Geoka~~]]

[[Category: Geobacillus kaustophilus HTA426]]

[[Category: Large Structures]]

[[Category: Chang, Y W]]

[[Category: Chang Y-W]]

[[Category: Chien, C H]]

[[Category: Chien C-H]]

[[Category: Hsiao, C D]]

[[Category: Hsiao C-D]]

[[Category: Naveen, V]]

[[Category: Naveen V]]

[[Category: Wu, C C]]

[[Category: Wu C-C]]

~~[[Category: Chaperone]]~~

~~[[Category: Chaperone cycle]]~~

~~[[Category: Complementary assay~~]]

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@@ Line 3: / Line 3: @@
 <StructureSection load='4ani' size='340' side='right'caption='[[4ani]], [[Resolution|resolution]] 4.09&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4ani]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Geoka Geoka]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ANI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ANI FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4ani]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_kaustophilus_HTA426 Geobacillus kaustophilus HTA426]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ANI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ANI FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2v7y|2v7y]]</div></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.094&#8491;</td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ani FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ani OCA], [https://pdbe.org/4ani PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ani RCSB], [https://www.ebi.ac.uk/pdbsum/4ani PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ani ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/GRPE_GEOKA GRPE_GEOKA]] Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding (By similarity). [[https://www.uniprot.org/uniprot/DNAK_GEOKA DNAK_GEOKA]] Acts as a chaperone (By similarity).
+[https://www.uniprot.org/uniprot/GRPE_GEOKA GRPE_GEOKA] Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding (By similarity).
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 25: / Line 25: @@
 __TOC__
 </StructureSection>
-[[Category: Geoka]]
+[[Category: Geobacillus kaustophilus HTA426]]
 [[Category: Large Structures]]
-[[Category: Chang, Y W]]
+[[Category: Chang Y-W]]
-[[Category: Chien, C H]]
+[[Category: Chien C-H]]
-[[Category: Hsiao, C D]]
+[[Category: Hsiao C-D]]
-[[Category: Naveen, V]]
+[[Category: Naveen V]]
-[[Category: Wu, C C]]
+[[Category: Wu C-C]]
-[[Category: Chaperone]]
-[[Category: Chaperone cycle]]
-[[Category: Complementary assay]]