4aw3: Difference between revisions

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<StructureSection load='4aw3' size='340' side='right'caption='[[4aw3]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
<StructureSection load='4aw3' size='340' side='right'caption='[[4aw3]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4aw3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/'micromonospora_griseorubida' 'micromonospora griseorubida']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AW3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AW3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4aw3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Micromonospora_griseorubida Micromonospora griseorubida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AW3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AW3 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MYV:MYCINAMICIN+V'>MYV</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2y46|2y46]], [[2y5n|2y5n]], [[2y5z|2y5z]], [[2y98|2y98]], [[2yca|2yca]], [[2ygx|2ygx]], [[3zsn|3zsn]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MYV:MYCINAMICIN+V'>MYV</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aw3 OCA], [https://pdbe.org/4aw3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aw3 RCSB], [https://www.ebi.ac.uk/pdbsum/4aw3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aw3 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4aw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aw3 OCA], [https://pdbe.org/4aw3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4aw3 RCSB], [https://www.ebi.ac.uk/pdbsum/4aw3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4aw3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MYCG_MICGR MYCG_MICGR] Involved in the biosynthesis of mycinamicin, a 16-membered macrolide antibiotic. Catalyzes consecutive hydroxylation (at C14) and epoxidation (at C12-C13) reactions with mycinamicin IV as initial substrate, leading to mycinamicin II. These reactions require prior dimethylation of 6-deoxyallose to mycinose for effective conversion by the dual function MycG enzyme.<ref>PMID:18804032</ref> <ref>PMID:22547618</ref> <ref>PMID:7808395</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Micromonospora griseorubida]]
[[Category: Micromonospora griseorubida]]
[[Category: Large Structures]]
[[Category: Anzai Y]]
[[Category: Anzai, Y]]
[[Category: Kato F]]
[[Category: Kato, F]]
[[Category: Kells PM]]
[[Category: Kells, P M]]
[[Category: Li S]]
[[Category: Li, S]]
[[Category: Pochapsky TC]]
[[Category: Pochapsky, T C]]
[[Category: Podust LM]]
[[Category: Podust, L M]]
[[Category: Rutaganira FU]]
[[Category: Rutaganira, F U]]
[[Category: Sherman DH]]
[[Category: Sherman, D H]]
[[Category: Tietz DR]]
[[Category: Tietz, D R]]
[[Category: Mycinamicin biosynthesis]]
[[Category: Oxidoreductase]]
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