1ic0: Difference between revisions

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[[Image:1ic0.gif|left|200px]]


<!--
==RED COPPER PROTEIN NITROSOCYANIN FROM NITROSOMONAS EUROPAEA==
The line below this paragraph, containing "STRUCTURE_1ic0", creates the "Structure Box" on the page.
<StructureSection load='1ic0' size='340' side='right'caption='[[1ic0]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1ic0]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Nitrosomonas_europaea Nitrosomonas europaea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IC0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IC0 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr>
{{STRUCTURE_1ic0|  PDB=1ic0  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ic0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ic0 OCA], [https://pdbe.org/1ic0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ic0 RCSB], [https://www.ebi.ac.uk/pdbsum/1ic0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ic0 ProSAT]</span></td></tr>
 
</table>
'''RED COPPER PROTEIN NITROSOCYANIN FROM NITROSOMONAS EUROPAEA'''
== Function ==
 
[https://www.uniprot.org/uniprot/Q820S6_NITEU Q820S6_NITEU]  
 
== Evolutionary Conservation ==
==Overview==
[[Image:Consurf_key_small.gif|200px|right]]
Nitrosocyanin (NC) is a mononuclear red copper protein isolated from the ammonia oxidizing bacterium Nitrosomonas europaea. Although NC exhibits some sequence homology to classic blue copper proteins, its spectroscopic and electrochemical properties are drastically different. The 1.65 A resolution crystal structure of oxidized NC reveals an unprecedented trimer of single domain cupredoxins. Each copper center is partially covered by an unusual extended beta-hairpin structure from an adjacent monomer. The copper ion is coordinated by His 98, His 103, Cys 95, a single side chain oxygen of Glu 60, and a solvent molecule. In the 2.3 A resolution structure of reduced NC, His 98 shifts away from the copper ion, and the solvent molecule is not observed. The arrangement of these ligands renders the coordination geometry of the NC red copper center distinct from that of blue copper centers. In particular, the red copper center has a higher coordination number and lacks the long Cu-S(Met) and short Cu-S(Cys) bond distances characteristic of blue copper. Moreover, the red copper center is square pyramidal whereas blue copper is typically distorted tetrahedral. Analysis of the NC structure provides insight into possible functions of this new type of biological copper center.
Check<jmol>
 
  <jmolCheckbox>
==About this Structure==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ic/1ic0_consurf.spt"</scriptWhenChecked>
1IC0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Nitrosomonas_europaea Nitrosomonas europaea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IC0 OCA].  
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==Reference==
  </jmolCheckbox>
Crystal structure of a novel red copper protein from Nitrosomonas europaea., Lieberman RL, Arciero DM, Hooper AB, Rosenzweig AC, Biochemistry. 2001 May 15;40(19):5674-81. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11341832 11341832]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ic0 ConSurf].
[[Category: Nitrosomonas europaea]]
<div style="clear:both"></div>
[[Category: Single protein]]
__TOC__
[[Category: Arciero, D M.]]
</StructureSection>
[[Category: Hooper, A B.]]
[[Category: Large Structures]]
[[Category: Lieberman, R L.]]
[[Category: Rosenzweig, A C.]]
[[Category: Beta hairpin]]
[[Category: Cu-mad]]
[[Category: Cupredoxin]]
[[Category: Nitrosocyanin]]
[[Category: Nitrosomonas europaea]]
[[Category: Nitrosomonas europaea]]
[[Category: Red copper]]
[[Category: Arciero DM]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 19:49:40 2008''
[[Category: Hooper AB]]
[[Category: Lieberman RL]]
[[Category: Rosenzweig AC]]
Retrieved from "https://proteopedia.org/1ic0"