8ef4: Difference between revisions
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New page: '''Unreleased structure''' The entry 8ef4 is ON HOLD Authors: Mishra, S.H., Bhavaraju, S. Description: Solution structural bundle of bivalirudin -a bivalent hirudin based thrombin inhi... |
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==Solution structural bundle of bivalirudin - a bivalent hirudin based thrombin inhibitor== | |||
<StructureSection load='8ef4' size='340' side='right'caption='[[8ef4]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8ef4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hirudo_medicinalis Hirudo medicinalis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EF4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EF4 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, models</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DPN:D-PHENYLALANINE'>DPN</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ef4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ef4 OCA], [https://pdbe.org/8ef4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ef4 RCSB], [https://www.ebi.ac.uk/pdbsum/8ef4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ef4 ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/HIRV2_HIRME HIRV2_HIRME] Hirudin is a potent thrombin-specific protease inhibitor. It forms a stable non-covalent complex with alpha-thrombin, thereby abolishing its ability to cleave fibrinogen. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Hirudo medicinalis]] | |||
[[Category: Large Structures]] | |||
[[Category: Bhavaraju S]] | |||
[[Category: Mishra SH]] | |||
Latest revision as of 15:07, 13 August 2026
Solution structural bundle of bivalirudin - a bivalent hirudin based thrombin inhibitor
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