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[[Image:1icl.jpg|left|200px]]


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==SOLUTION STRUCTURE OF DESIGNED BETA-SHEET MINI-PROTEIN TH1OX==
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<StructureSection load='1icl' size='340' side='right'caption='[[1icl]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1icl]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ICL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ICL FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 38 models</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DPR:D-PROLINE'>DPR</scene></td></tr>
{{STRUCTURE_1icl| PDB=1icl  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1icl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1icl OCA], [https://pdbe.org/1icl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1icl RCSB], [https://www.ebi.ac.uk/pdbsum/1icl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1icl ProSAT]</span></td></tr>
 
</table>
'''SOLUTION STRUCTURE OF DESIGNED BETA-SHEET MINI-PROTEIN TH1OX'''
<div style="background-color:#fffaf0;">
 
== Publication Abstract from PubMed ==
 
==Overview==
Here we report the creation of a predominantly beta-structured mini-protein motif. The design target is based on the naturally occurring toxin hand (TH) motifs that are composed of four disulfide bonds and three loops that form a 'hand'. Analysis and subsequent modification of several generations of mini-proteins produced the final 29-residue mini-protein. The structured motif of this new mini-protein provides insight into the compensatory changes that result in the formation of a tightly packed hydrophobic core in a small, globular beta-structure motif. Additionally, this mini-motif represents a new, distinct surface topology for protein design and a valuable, yet compact, model system for the study of beta-sheet structure in water.
Here we report the creation of a predominantly beta-structured mini-protein motif. The design target is based on the naturally occurring toxin hand (TH) motifs that are composed of four disulfide bonds and three loops that form a 'hand'. Analysis and subsequent modification of several generations of mini-proteins produced the final 29-residue mini-protein. The structured motif of this new mini-protein provides insight into the compensatory changes that result in the formation of a tightly packed hydrophobic core in a small, globular beta-structure motif. Additionally, this mini-motif represents a new, distinct surface topology for protein design and a valuable, yet compact, model system for the study of beta-sheet structure in water.


==About this Structure==
Design of a discretely folded mini-protein motif with predominantly beta-structure.,Ottesen JJ, Imperiali B Nat Struct Biol. 2001 Jun;8(6):535-9. PMID:11373623<ref>PMID:11373623</ref>
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ICL OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
Design of a discretely folded mini-protein motif with predominantly beta-structure., Ottesen JJ, Imperiali B, Nat Struct Biol. 2001 Jun;8(6):535-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11373623 11373623]
</div>
[[Category: Imperiali, B.]]
<div class="pdbe-citations 1icl" style="background-color:#fffaf0;"></div>
[[Category: Ottesen, J J.]]
== References ==
[[Category: De novo protein design three-stranded beta-sheet mini-protein motif th motif]]
<references/>
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 19:50:53 2008''
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</StructureSection>
[[Category: Large Structures]]
[[Category: Imperiali B]]
[[Category: Ottesen JJ]]
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