8gvf: Difference between revisions
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The | ==The outward-facing structure of hAE2 in basic pH== | ||
<StructureSection load='8gvf' size='340' side='right'caption='[[8gvf]], [[Resolution|resolution]] 3.09Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8gvf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GVF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GVF FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.09Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gvf OCA], [https://pdbe.org/8gvf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gvf RCSB], [https://www.ebi.ac.uk/pdbsum/8gvf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gvf ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/B3A2_HUMAN B3A2_HUMAN] The disease may be caused by variants affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/B3A2_HUMAN B3A2_HUMAN] Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (PubMed:15184086, PubMed:34668226). Plays an important role in osteoclast differentiation and function (PubMed:34668226). Regulates bone resorption and calpain-dependent actin cytoskeleton organization in osteoclasts via anion exchange-dependent control of pH (By similarity). Essential for intracellular pH regulation in CD8(+) T-cells upon CD3 stimulation, modulating CD8(+) T-cell responses (By similarity).[UniProtKB:P13808]<ref>PMID:15184086</ref> <ref>PMID:34668226</ref> | |||
==See Also== | |||
*[[Anion exchange protein 3D structures|Anion exchange protein 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: Hu | [[Category: Homo sapiens]] | ||
[[Category: Jian | [[Category: Large Structures]] | ||
[[Category: | [[Category: Cao Y]] | ||
[[Category: Xia | [[Category: Hu K]] | ||
[[Category: Zhang | [[Category: Jian L]] | ||
[[Category: Rao B]] | |||
[[Category: Xia Y]] | |||
[[Category: Yao D]] | |||
[[Category: Zhang Q]] | |||
Latest revision as of 06:50, 19 June 2024
The outward-facing structure of hAE2 in basic pH
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