8h2n: Difference between revisions

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'''Unreleased structure'''


The entry 8h2n is ON HOLD  until Paper Publication
==gp96 RNA polymerase from P23-45 phage (crystal 2)==
<StructureSection load='8h2n' size='340' side='right'caption='[[8h2n]], [[Resolution|resolution]] 4.41&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8h2n]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_virus_P23-45 Thermus virus P23-45]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8H2N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8H2N FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.41&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8h2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8h2n OCA], [https://pdbe.org/8h2n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8h2n RCSB], [https://www.ebi.ac.uk/pdbsum/8h2n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8h2n ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A7XXD0_BP234 A7XXD0_BP234]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Thermus thermophilus bacteriophage P23-45 encodes a giant 5,002-residue tail tape measure protein (TMP) that defines the length of its extraordinarily long tail. Here, we show that the N-terminal portion of P23-45 TMP is an unusual RNA polymerase (RNAP) homologous to cellular RNAPs. The TMP-fused virion RNAP transcribes pre-early phage genes, including a gene that encodes another, non-virion RNAP, that transcribes early and some middle phage genes. We report the crystal structures of both P23-45 RNAPs. The non-virion RNAP has a crab-claw-like architecture. By contrast, the virion RNAP adopts a unique flat structure without a clamp. Structure and sequence comparisons of the P23-45 RNAPs with other RNAPs suggest that, despite the extensive functional differences, the two P23-45 RNAPs originate from an ancient gene duplication in an ancestral phage. Our findings demonstrate striking adaptability of RNAPs that can be attained within a single virus species.


Authors:  
Tail-tape-fused virion and non-virion RNA polymerases of a thermophilic virus with an extremely long tail.,Chaban A, Minakhin L, Goldobina E, Bae B, Hao Y, Borukhov S, Putzeys L, Boon M, Kabinger F, Lavigne R, Makarova KS, Koonin EV, Nair SK, Tagami S, Severinov K, Sokolova ML Nat Commun. 2024 Jan 5;15(1):317. doi: 10.1038/s41467-023-44630-z. PMID:38182597<ref>PMID:38182597</ref>


Description:  
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
<div class="pdbe-citations 8h2n" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Thermus virus P23-45]]
[[Category: Chaban A]]
[[Category: Sokolova ML]]
[[Category: Tagami S]]
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