8bcr: Difference between revisions
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New page: '''Unreleased structure''' The entry 8bcr is ON HOLD Authors: Gauffre, P., Fattorini, V., Canard, B., Ferron, F. Description: DENV3 Methyltransferase in complexed with AT-9010 and SAH ... |
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==DENV3 Methyltransferase in complexed with AT-9010 and SAH== | |||
<StructureSection load='8bcr' size='340' side='right'caption='[[8bcr]], [[Resolution|resolution]] 1.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8bcr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_3 Dengue virus 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BCR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BCR FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AT9:[[(2~{R},3~{R},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-4-fluoranyl-4-methyl-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]+phosphono+hydrogen+phosphate'>AT9</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bcr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bcr OCA], [https://pdbe.org/8bcr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bcr RCSB], [https://www.ebi.ac.uk/pdbsum/8bcr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bcr ProSAT]</span></td></tr> | ||
[[Category: Canard | </table> | ||
[[Category: Fattorini | == Function == | ||
[[Category: Gauffre | [https://www.uniprot.org/uniprot/A9LIE0_9FLAV A9LIE0_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS013754_004_099774] | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Dengue virus 3]] | |||
[[Category: Large Structures]] | |||
[[Category: Canard B]] | |||
[[Category: Fattorini V]] | |||
[[Category: Ferron F]] | |||
[[Category: Gauffre P]] | |||
Latest revision as of 08:49, 11 December 2025
DENV3 Methyltransferase in complexed with AT-9010 and SAH
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